Simple DNS Plus is part of the solution, but you also need a web-server that supports this.
A URL consists of 3 parts: Protocol (http://), Domain Name (www.domain.com), and Path/File (/somedir/page.htm).
The Protocol tells the browser how to communicate with the web server.
The Domain Name is used to locate the IP address of the web server (through DNS).
The Path/File is sent to the web server as part of the http request.
When a browser opens a web-page, it first locates the web server's IP address through DNS. This DNS request only contains the Domain Name - not the Path/File.
Second it connects to the web server and sends a HTTP request, which includes both the Domain Name and Path/File.
If the web server supports different domain names, it then serves the page from a directory according to the domain name supplied in the request.
This is supported directly by Microsoft IIS (Internet Information Server) for all current Windows versions - click here to see how
There are also several free / inexpensive web servers available that do support it directly on all Windows platforms. For example:
This is the "original" and still the most widely used web-server on the Internet.
It is free (or OpenSource), but because it uses text configuration files instead of a GUI, it is probably not the most user friendly choice on Windows.
And it is also supported directly by Apache.
For information about virtual hosting with Apache, see
"Abyss web server" http://www.aprelium.com